The human body has a regenerative (and recycling) organ system the grand overview of how the body is capable of infinite healing, as originally divined:
The kidney is the "brain' of this system;
The bone marrow is the "spinal cord" of this system;
The individual cellular members of this system, are located in every organ and tissue, waiting to be activated or triggered.
These cells have been well described by the brilliant, original, talented, future Nobel winner, Dr. Arjun Raj of UPENN, and constitute immortal cells.
It is this regenerative organ system, that prevents the body from aging, acquiring any disease, and dying; and prevents the need for the inauguration and relentless (once initiated) execution of what we at immortality call the "final common pathway of organismal, aging, disease and demise".
It is this pathway that we've been studying for over 9 years, at the immortality institute, located in Houston, Texas.
Within this system, the kidney triggers new hematopoietic stem cell generation from hemangioblasts, along with endothelial progenitor cells.
It also secretes g-csf and erythropoietin, which stimulate the bone marrow in hematopoiesis.
This regenerative function of the kidney, does not depend upon actually its perfusion or egfr. Indeed, only a sliver of kidney (with intact regenerative function), is required, to carry out the property of being the brain of the regenerative organ system. Also, this implies, that the signals being transmitted to the kidney, arise in the neurons in the blood vessel walls, of vessels to the kidney, rather than in the actual quantum of blood flow or supply, to the kidney.
Interestingly, we have demonstrated based on clinical observations, that we can probably induce greater numbers and pluripotency of hematopoietic stem cells, which are the one truly pluripotent stem cells, which already exist in the body (and are accessible via mobilization - including utilizing our protocol, in circulation in the elderly, and just like that, in the young), can travel all over the body within blood regenerating where they need to.
However, wherever there are still capillaries, be they lymphatic or vascular, there exists the possibility of transforming capillary endothelial cells, into hematopoietic stem cells, which can potentially regenerate the tissue as well. The analogy for this, is when the bricks of the road that is laid, turn into the construction workers, laying not only the highway, but also, the public utilities, lighting and nearby township, which they can only get to, by traversing the newly laid highway - an infinite, and gorgeously (one is sure) regulated loop the loop.
This endothelial hematopoietic transition likely occurs under hypoxic (when blood supply is preferentially diverted elsewhere by the parasympathetic nervous system, during stress) conditions, but where neuronal signals still can reach. Obviously therefore, the inverse must also occur (hematopoietic endothelial transformation). This, we are observing clinically, when utilizing our protocol.
Eht transition is perhaps limited by neuronal access (within capillary walls), to endothelial cells; neuronal access to endothelium, is enhanced by meditation, which redirects blood flow, to the luminal surface of all tubular structures within the body, by the parasympathetic nervous system, which is constantly active, with prolonged states of meditation.
The regenerative function of the kidney is lost when there is chronic stress.
The recycling and regenerative function of the kidney, that is.
When it stops recycling, it must excrete nitrogenous, what are now "wastes".
That is when and where, its excretory function comes into a necessary play.
This is also why, we've never been able to correctly predict, 100 % of the time, unlike say, heart failure or liver failure, exactly what the functional status of the kidney - we are still devising exponential formulae, to calculate in every scenario of kidney failure, its correct function (that egfr, which tallies exactly, with what it's measured gold standard filtration rate is).